Bibliografia dei prodotti Minerva Medica

  1. International Headache Society, Headache Classification Committee. The international classification of headache disorders, 3rd edition (beta version). 2013;33:629-808.

DOI: 10.1177/0333102413485658

  1. Chowdhury D. Tension type headache. Ann Indian Acad Neurol. 2012 Aug; 15(Suppl 1): S83–S88.

DOI: 10.4103/0972-2327.100023

  1. Jensen RH. Tension-Type Headache – The Normal and Most Prevalent Headache. 2018 Feb;58(2):339-345.

DOI: 10.1111/head.13067

  1. Bendtsen L, Fernández de la Peñas. The Role of Muscles in Tension-Type Headache. Curr Pain Headache Rep 15, 451–458 (2011).

DOI: 10.1007/s11916-011-0216-0

  1. Fernandes G, Franco AL, Gonçalves DA, Speciali JG, Bigal ME, Camparis CM. Temporomandibular disorders, sleep bruxism, and primary headaches are mutually associated. J Orofac Pain. 2013 Winter;27(1):14-20.

DOI: 10.11607/jop.921

  1. Cathcart S, Winefield AH, Lushington K, Rolan P. Stress and tension-type headache mechanisms. 2010 Oct;30(10):1250-67.

DOI: 10.1177/0333102410362927

  1. Fernández-de-Las-Peñas C, Fernández-Muñoz JJ, Palacios-Ceña M, Parás-Bravo P, Cigarán-Méndez M, Navarro-Pardo E. Sleep disturbances in tension-type headache and migraine. Ther Adv Neurol Disord. 2017;11:1756285617745444. Published 2017 Dec 6.

DOI: 10.1177/1756285617745444

  1. Song TJ, Cho SJ, Kim WJ, Yang KI, Yun CH, Chu MK. Anxiety and Depression in Tension-Type Headache: A Population-Based Study. PLoS One. 2016 Oct 26;11(10):e0165316.

DOI: 10.1371/journal.pone.0165316 

  1. Katz RS, Swiatnicki K. Muscle Tension Is Increased Katz RS, Swiatnicki K. Muscle Tension Is Increased in Fibromyalgia. 2014 ACR/ARHP Annual Meeting.
  1. Keskindag B, Karaaziz M. The association between pain and sleep in fibromyalgia. Saudi Med J. 2017;38(5):465-475.

DOI: 10.15537/smj.2017.5.17864 

  1. Consoli G, Marazziti D, Ciapparelli A, Bazzichi L, Massimetti G, Giacomelli C, Rossi A, Bombardieri S, Dell’Osso L. The impact of mood, anxiety, and sleep disorders on fibromyalgia. Compr Psychiatry. 2012 Oct;53(7):962-7.

DOI: 10.1016/j.comppsych.2012.03.008 

  1. Altura BM, Altura BT. Tension headaches and muscle tension: is there a role for magnesium? Med Hypotheses. 2001 Dec;57(6):705-13.

     DOI: 10.1054/mehy.2001.1439 

  1. rer. nat. Stefan Siebrecht. Magnesium Bisglycinate as safe form for mineral supplementation in human nutrition. OM & Ernährung 2013. Nr. 144.
  1. Siddiqui MZ. Boswellia Serrata, A Potential Antiinflammatory Agent: An Overview. Indian J Pharm Sci. 2011 May-Jun; 73(3): 255–261.

DOI: 10.4103/0250-474X.93507 

  1. Birdsall TC. 5-Hydroxytryptophan: a clinically-effective serotonin precursor. Altern Med Rev. 1998 Aug;3(4):271-80.
  1. Kikuchi AM, Tanabe A, Iwahori Y. A systematic review of the effect of Ltryptophan supplementation on mood and emotional functioning. J Diet Suppl. 2021;18(3):316-333.

DOI: 10.1080/19390211.2020.1746725 

  1. Blankfield A. A Brief Historic Overview of Clinical Disorders Associated with Tryptophan: The Relevance to Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM). J. Tryptophan Res. 2012; 5:27-32.

DOI: 10.4137/IJTR.S10085 

  1. Didangelos T, Karlafti E, Kotzakioulafi E, Kontoninas Z, Margaritidis C, Giannoulaki P, Kantartzis K. Efficacy and Safety of the Combination of Superoxide Dismutase, Alpha Lipoic Acid, Vitamin B , and Carnitine for 12 Months in Patients with Diabetic Neuropathy. 2020 Oct 23;12(11):3254.

DOI: 10.3390/nu12113254 

  1. Treede R.D., Jensen T.S., et al. Neurophatic Pain: redefinition and a grading system for clinical and research purposes. Neurology. 2008; 70:1630-5.

DOI: 10.1212/01.wnl.0000282763.29778.59 

  1. Parker L., Witt E.H., Titscheler H.J., Wessel K.. Alpha-Lipoic Acid as a biological antioxidant. Free Radic. Biol. Med. 1997; 19(2):227-50.

DOI: 10.1016/0891-5849(95)00017-r 

  1. Parker L., Witt E.H.., Titscheler H.J., Wessel K.. Neuroprotection by the metabolic antioxidant alpha-lipic acid.Free Radic. Biol. Med. 1997; 22(1-2):359-78.

DOI: 10.1016/s0891-5849(96)00269-9 

  1. Nozik-Grayck E., Suliman H.B., Piantadosi A..   Extracellular   Superoxide Dismutase. Int.J. Biochem. Cell. Biol. 2005; 37(12): 2466-71.

DOI: 10.1016/j.biocel.2005.06.012 

  1. Fattman C.L., Schaefer L.M., Outy T.D.. Extracellular superoxide dismutase in biology and medicine. Free Radic. Biol. Med. 2003; 35(3):236-56.

DOI: 10.1016/s0891-5849(03)00275-2 

  1. Chiechio S., Copani A., Gereau R.W., Nicoletti F.. Acetyl-L-carnitine in neuropathic pain: experimental data. CNS Drugs. 2007; 21 Supl. 1:31-8.

DOI: 10.2165/00023210-200721001-00005 

  1. Ribas G.S., Vargas C.R., Wajner M.. L-carnitine supplementation as a potential antioxidant therapy for inherited neurometabolic disorders. 2013; pii: S0378-1119(13) 01411-X.

DOI: 10.1016/j.gene.2013.10.017 

  1. EFSA Panel of Dietetic Products, Nutrition and Allergies. Scientific opinion on the substantion of health claims related of Vitamin B and contibution to normal neurological and psychological functions. EFSA Journal. 2012; 8(10):1756

DOI: 10.2903/j.efsa.2010.1759 

  1. Basit S. Vitamin D in health and disease: a literature review. Br J Biomed Sci. 2013;70(4):161-72.

DOI: 10.1080/09674845.2013.11669951

  1. Lips P, van Schoor NM. The effect of vitamin D on bone and osteoporosis. Best Pract Res Clin Endocrinol Metab. 2011 Aug;25(4):585-91.

DOI: 10.1016/j.beem.2011.05.002

  1. Venning G. Recent developments in vitamin D deficiency and muscle weakness among elderly people. 2005;330(7490):524-526. doi:10.1136/bmj.330.7490.524

DOI: 10.1136/bmj.330.7490.524

  1. Hennie CJP Janssen, Monique M Samson,  Harald  JJ  Verhaar,  Vitamin  D deficiency, muscle function, and falls in elderly people, The American Journal of Clinical Nutrition, Volume 75, Issue 4, April 2002, Pages 611–615.

DOI: 10.1093/ajcn/75.4.611

  1. Antico A, Tampoia M, Tozzoli R. Il ruolo della Vitamina D  nelle  malattie autoimmuni. Ligand Assay 15(4) 2010
  1. Gatenby P, Lucas R, Swaminathan A. Vitamin D deficiency and risk for rheumatic diseases: an update. Curr Opin Rheumatol. 2013 Mar;25(2):184-91.

DOI: 10.1097/BOR.0b013e32835cfc16

  1. Franco AS, Freitas TQ, Bernardo WM, Pereira RMR. Vitamin D supplementation and disease activity in patients with immune-mediated rheumatic diseases: A systematic review and meta-analysis. Medicine (Baltimore). 2017;96(23):e7024.

DOI: 10.1097/MD.0000000000007024

  1. Makrani AH, Afshari M, Ghajar M, Forooghi Z, Moosazadeh M. Vitamin D and fibromyalgia: a meta-analysis. Korean J Pain. 2017;30(4):250-257. doi:10.3344/kjp.2017.30.4.250

DOI: 10.3344/kjp.2017.30.4.250

  1. Jesus CA, Feder D, Peres MF. The role of vitamin D in pathophysiology and treatment of fibromyalgia. Curr Pain Headache Rep. 2013 Aug;17(8):355.

DOI: 10.1007/s11916-013-0355-6

  1. Muscogiuri G, Tirabassi G, Bizzaro G, Orio F, Paschou SA, Vryonidou A, Balercia G, Shoenfeld Y, Colao A. Vitamin D and thyroid disease: to D or not to D? Eur J Clin Nutr. 2015 Mar;69(3):291-6.

DOI: 10.1038/ejcn.2014.265

  1. Chao G, Zhu Y, Fang L. Correlation Between Hashimoto’s Thyroiditis-Related Thyroid Hormone Levels and 25-Hydroxyvitamin D. Front Endocrinol (Lausanne). 2020 Feb 14;11:4.

DOI: 10.3389/fendo.2020.00004

  1. Anastasiou CA, Yannakoulia M, Scarmeas N. Vitamin D and cognition: an update of the current evidence. J Alzheimers Dis. 2014;42 Suppl 3:S71-80.

DOI: 10.3233/JAD-132636

  1. Sultan S, Taimuri U, Basnan SA, et al. Low Vitamin D and Its Association with Cognitive Impairment and Dementia. J Aging Res. 2020;2020:6097820. Published 2020 Apr 30.

DOI: 10.1155/2020/6097820

  1. Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL,  Cherubini  A, Ferrucci L, Melzer D. Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med. 2010 Jul 12;170(13):1135-41. doi: 10.1001/archinternmed.2010.173. PMID: 20625021; PMCID: PMC4053858.

DOI: 10.1001/archinternmed.2010.173

  1. Jigna Shah and Sakshi Gurbani. Association of Vitamin D Deficiency and Mood Disorders: A Systematic Review. In book: Vitamin D Deficiency. December 2019

DOI: 10.1093/qjmed/hcab009

  1. Berridge MJ. Vitamin D and Depression: Cellular and Regulatory Mechanisms. Pharmacol Rev. 2017 Apr;69(2):80-92.

 DOI: 10.4103/IJPSYM.IJPSYM_160_19

  1. Bischoff-Ferrari HA, Dawson-Hughes B, Orav EJ, Staehelin HB, Meyer OW, Theiler R, Dick W, Willett WC, Egli A. Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline: A Randomized Clinical Trial. JAMA Intern Med. 2016 Feb;176(2):175-83.

 DOI: 10.1001/jamainternmed.2015.7148

  1. Hansen KE, Johnson MG. An update on vitamin D for clinicians. Curr Opin Endocrinol Diabetes Obes. 2016;23(6):440-444.

 DOI: 10.1097/MED.0000000000000288

  1. Bischoff-Ferrari HA, Dawson-Hughes B, Orav EJ, Staehelin HB, Meyer OW, Theiler R, Dick W, Willett WC, Egli A. Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline: A Randomized Clinical Trial. JAMA Intern Med. 2016 Feb;176(2):175-83.

 DOI: 10.1001/jamainternmed.2015.7148

  1. Schwedhelm E, et al. Pharmacikinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. In. of Exp. and Clin. Pharmac. and Toxicol. Univ. Med. Cen. Hamburg-Eppendorf. Germany.


  1. Cormio L, et al. Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. 2011 Jan; 77(1):119-22.

DOI: 10.1016/j.urology.2010.08.028

  1. Bendhan D, et   Citrulline/maate  promotes  aerobic  energy  production  in human exercising muscle. Br J Sports Med. 2002 Aug;36(4):282-9.

DOI: 10.1136/bjsm.36.4.282

  1. Romero M, et al. Therapeutic use of L-citrulline in Cardiovascular diseases. Cardiovascular Drug Reviews Vol.24, N.3-4, pp 275-290.

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  1. Ohtsuka Y, et al. Effects of oral administration of L-arginine on senile dementia. Am J Med. 2000;108:439.

DOI: 10.1016/s0002-9343(99)00396-4

  1. Jing Yi, et al. L-arginine and Alzheimer’s disease. Int J Clin Exp Pathol, 2009:3,211- 238.
  1. Oltof Mr, et al. Low dose of betaine supplementation leads to immediate and long term lowering of plasma homocysteine in healthy men and women. J Nutr 2003;133:4135-8.

DOI: 10.1093/jn/133.12.4135

  1. Hoffman JR et al. Effect of betaine supplementation on power performance and fatigue. J Int Soc Sports Nutr. 2009 Feb:27;6-7.

DOI: 10.1186/1550-2783-6-7

  1. Di Pierro F et al. Role of betaine in improving the antidepressant effect of S- adenosyl-methionine in patients with mild – to – moderate depression. J Multidiscip Healthc. 2015 Jan 16;8:39-45.

DOI: 10.2147/JMDH.S77766

  1. Delwaide PJ, et al. Double blind randomized controlled study of Phosphatidylserine in senile demented patient. Acta Neurol Scand. 1986:73;136-140.

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  1. Schreibel et al. An open trial of plant-source derived Phosphatidylserine for the treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci. 2000:37:302- 307.
  1. Gärtner R, Gasnier BC, Dietrich JW, Krebs B, Angstwurm MW.,Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxydase antibodies concentrations. J. Clin. Metab. 2002. Apr;87(4):1687-91.

DOI: 10.1210/jcem.87.4.8421

  1. Duntas LH, Mantzou E, Koutras DA.,Effects of a six month treatment with selenomethionine in patients with autoimmune thyroiditis. Eur. J. Endocrinol., 2003 Apr;148(4):389-93.

DOI: 10.1530/eje.0.1480389

  1. Turker O, Kumanlioglu K, Karapolat I, Dogan I.,Selenium treatment in autoimmune thyroiditis: 9-month follow-up with variable doses. J. Endocrinol., 2006 Jul;190(1):151-6.

DOI: 10.1677/joe.1.06661

  1. Nacamulli D, Mian C, Petricca D, Lazzarotto F, Barollo S, Pozza D, Masiero S, Faggian D, Plebani M, Girelli ME, Mantero F, Betterle C., Influence of physiological dietary autoimmune thyroiditis. Clin. Endocrinol. (Oxf) 2010 Oct;73(4):535-9.

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  1. Beckett GJ, Arthur, Selenium and endocrine systems.     J. Endocrinol. 2005 Mar;184(3):455-65.

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  1. Rayman MP.,The importance of selenium human Lancet 2000 Jul 15;356(9225):233-41.

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  1. REGOLAMENTO (UE) N. 432/2012 DELLA COMMISSIONE – del 16 maggio 2012 relativo alla compilazione di un elenco di indicazioni sulla salute consentite sui prodotti alimentari, diverse da quelle facenti riferimento alla riduzione dei rischi di malattia e allo sviluppo e alla salute.
  1. LeungA,PearceEN,BravermanLE.Role of iodine in thyroid physiology. Expert Rev Endocrinol Metab 2010; 5(4): 593‒602.

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  1. Carrasco MN.Thyroid hormone synthesis. In: The Thyroid. PA: Lippincott Wilkins; 2005.p.7‒76.
  1. CS Hotz, DW Fitzpatrick, KD Trick,MR L’Abbé. Dietary Iodine and selenium interact to affect thyroid hormone metabolism of rats. JNutr 1997 Jun;127(6):1214-8.

DOI: 10.1093/jn/127.6.1214

  1. Triggiani V, Tafaro E, G giaguli VA, et al. Role of iodine, selenium and other micronutrrients in thyroid function and disorders. Endocr Metab Immune Disord Drug Targets. 2009;9(3):277‒294.

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  1. GJ Beckett, F Nicol, PW Rae, S Beech, Y Guo, JR Arthur. Effects of combine diodine and selenium deficiency on thyroid hormone metabolism in rats. Am JClin Nutr 1993Feb;57(2Suppl):240S-243S.

DOI: 10.1093/ajcn/57.2.240S

  1. JH Mitchell, F Nicol, GJ Beckett, JR Arthur. Seleno enzyme expression in thyroid and liver of second-generation selenium-and iodine-deficien trats. J Mol Endocrinol. 1996Jun;16(3):259-67.

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  1. Raymond F.Burk, Kristina E.Hill, Joseph A.Awad, Jason D.Morrow, Tatsuko Kato, Kevin A.Cockell, P.Reid Lyons. Pathogenesis of diquat-induce d liver necrosis inselenium- deficient rats: Assessment of the roles of lipid peroxidat ion and selenoprotein. P.Hepatology-Volume21,Issue2,February1995,Pages561-569.

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  1. M. Abrams, P.R. Larsen. Triiodothyronine and thyroxine in theserum and thyroid glands of iodine-deficient rats. JClin Invest.1973Oct;52(10):2522–2531.

DOI: 10.1172/JCI107443 

  1. Vincent J. Erickson, Ralph R .Cavalieri, Lawson L. Rosenberg. Thyroxine-5&-Deiodinase of Rat Thyroid, But Not that of Liver, Is Dependent on Thyrotropin. Endocrinology, Volume111, Issue2,1 August1982,Pages434–440.

DOI: 10.1210/endo-111-2-434

  1. Chen JK, Shen CR, Liu CL. N-acetylglucosamine: production and applications. Mar Drugs. 2010;8(9):2493-2516. Published 2010 Sep 15.

DOI: 10.3390/md8092493

  1. Shikhman AR, Amiel D, D’Lima D, et al. Chondroprotective activity of N- acetylglucosamine in rabbits with experimental osteoarthritis. Ann Rheum Dis. 2005;64(1):89-94.


  1. Shikhman AR, Brinson DC, Valbracht J, Lotz MK. Differential metabolic effects of glucosamine and N-acetylglucosamine in human articular chondrocytes. Osteoarthritis Cartilage. 2009 Aug;17(8):1022-8.

DOI: 10.1016/j.joca.2009.03.004

  1. Hresko RC, Heimberg H, Chi MM, Mueckler M. Glucosamine-induced insulin resistance in 3T3-L1 adipocytes is caused by depletion of intracellular ATP. J Biol Chem. 1998 Aug 7;273(32):20658-68.

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  1. Nelson BA, Robinson KA, Buse MG. High glucose and glucosamine induce insulin resistance via different mechanisms in 3T3-L1 adipocytes. Diabetes. 2000 Jun;49(6):981- 91.

DOI: 10.2337/diabetes.49.6.981

  1. Bishnoi M, Jain A, Hurkat P, Jain SK. Chondroitin sulphate: a focus on osteoarthritis. Glycoconj J. 2016 Oct;33(5):693-705.

DOI: 10.1007/s10719-016-9665-3

  1. Hochberg MC. Structure-modifying effects of chondroitin sulfate in knee osteoarthritis: an updated meta-analysis of randomized placebo-controlled trials of 2-year duration. Osteoarthritis Cartilage. 2010 Jun;18 Suppl 1:S28-31.

DOI: 10.1016/j.joca.2010.02.016

  1. Wildi LM, Raynauld JP, Martel-Pelletier J, Beaulieu A, Bessette L, Morin F, Abram F, Dorais M, Pelletier JP. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI. Ann Rheum Dis. 2011 Jun;70(6):982-9.b

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  1. Richy F, Bruyere O, Ethgen O, Cucherat M, Henrotin Y, Reginster JY. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Arch Intern Med. 2003;163:1514–22.

DOI: 10.1001/archinte.163.13.1514

  1. Zhu X, Sang L, Wu D, Rong J, Jiang L. Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials. J Orthop Surg Res. 2018;13(1):170. Published 2018 Jul 6.

DOI: 10.1186/s13018-018-0871-5

  1. Debbi EM, Agar G, Fichman G, et al. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med. 2011;11:50. Published 2011 Jun 27.


  1. Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage. 2006 Mar;14(3):286-94.

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  1. Lubis AMT, Siagian C, Wonggokusuma E, Marsetyo AF, Setyohadi B. Comparison of Glucosamine-Chondroitin Sulfate with and without Methylsulfonylmethane in Grade I-II Knee Osteoarthritis: A Double Blind Randomized Controlled Trial. Acta Med Indones. 2017 Apr;49(2):105-111.
  1. Yu G, Xiang W, Zhang T, Zeng L, Yang K, Li J. Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis. BMC Complement Med Ther. 2020;20(1):225. Published 2020 Jul 17.


  1. Sontakke S, Thawani V, Pimpalkhute S, Kabra P, Babhulkar S, Hingorani L. Open, randomized, controlled clinical trial of Boswellia serrata extract as compared to valdecoxib in osteoarthritis of knee. Indian Journal of Pharmacology; Pondicherry Vol. 39, Fasc. 1, (Jan/Feb 2007): 27-29.
  1. Notarnicola A, Tafuri S, Fusaro L, Moretti L, Pesce V, Moretti B. The “MESACA” study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis. Adv Ther. 2011 Oct;28(10):894-906.

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  1. Ripani U, Manzarbeitia-Arroba P, Guijarro-Leo S, Urrutia-Graña J, De Masi-De Luca A. Vitamin C May Help to Reduce the Knee’s Arthritic Symptoms. Outcomes Assessment of Nutriceutical Therapy. Med Arch. 2019;73(3):173-177.

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  1. Dunlap B, Patterson GT, Kumar S, Vyavahare S, Mishra S, Isales C, Fulzele S. Vitamin C supplementation for the treatment of osteoarthritis: perspectives on the past, present, and future. Ther Adv Chronic Dis. 2021 Oct 20;12:20406223211047026.

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  1. Siddiqui MZ. Boswellia serrata, a potential antiinflammatory agent: an overview. Indian J Pharm Sci. 2011 May;73(3):255-61.

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  1. Ala-Jaakkola R, Laitila A, Ouwehand AC, Lehtoranta L. Role of D-mannose in urinary tract infections – a narrative review. Nutr J. 2022 Mar 22;21(1):18.


  1. De Nunzio C, Bartoletti R, Tubaro A, Simonato A, Ficarra V. Role of D-Mannose in the Prevention of Recurrent Uncomplicated Cystitis: State of the Art and Future Perspectives. Antibiotics (Basel). 2021;10(4):373. Published 2021 Apr 1.

DOI: 10.3390/antibiotics10040373

  1. Riaz G, Chopra R. A review on phytochemistry and therapeutic uses of Hibiscus sabdariffa L. Biomed Pharmacother. 2018 Jun;102:575-586. doi: 10.1016/j.biopha.2018.03.023.Epub 2018 Apr 5.
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  1. Bouridane H, Sifour M, Idoui T, Annick L, Thonard P. Technological and Probiotic Traits of the Lactobacilli Isolated From Vaginal Tract of the Healthy Women for Probiotic Use. Iran J Biotechnol. 2016 Sep;14(3):192-201.

DOI: 10.15171/ijb.1432

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  1. Pavan R, Jain S, Shraddha, Kumar A. Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203.


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